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Psychedelics Alcohol and Drug Foundation “There’s always a chance that when you’re trying to reduce hallucinations you supercharge them instead, or maybe you end up increasing cardiotoxicity instead of removing it,” Psilera’s von Salm notes. This profit motive isn’t a bad thing, Johns Hopkins’ Johnson says, since it incentivizes companies to conduct the extensive and expensive studies Psychedelics required to prove the drugs are safe and effective. “While big, definitive studies still need to be done, it’s looking increasingly clear that psychedelic medicines can be of enormous benefit to individuals with depression, addiction, and other common disorders,” says Christopher Pittenger, director of the Yale Program for Psychedelic Science. After intracerebroventricular injection, low doses of serotonin produced a robust HTR in mice that markedly exceeded those observed in β-arrestin-2 KO mice. In fact, with higher doses of serotonin, the HTR in β-arrestin-2 KO mice even exceeded the ...